Dr. Li Gan

The discovery of how to shift damaged brain cells from a diseased state into a healthy one poses a new potential path to treating Alzheimer’s and other forms of dementia.

Inhibiting an important signaling pathway in brain-resident immune cells may calm brain inflammation and thereby slow the disease process in Alzheimer’s and some other neurodegenerative diseases, suggests a study by Weill Cornell Medicine investigators.

By mapping all the protein interactions of a dementia-linked protein in the brain called Tau, a team of Weill Cornell Medicine investigators has created a road map for identifying potential new treatment targets for Alzheimer’s disease and related dementia.

A gene mutation linked to Alzheimer’s disease alters a signaling pathway in certain immune cells of individuals with the disease, according to a new study by scientists at Weill Cornell Medicine.

Some of the latest research discoveries in neurodegenerative disease and their potential therapeutic applications were featured at the ninth annual Appel Alzheimer's Disease Research Institute Symposium, held remotely on Nov. 9. 

Weill Cornell Medicine neuroscientist Dr. Li Gan is driving toward one of the most coveted medical breakthroughs: an effective treatment for Alzheimer’s disease.

Investigators on the forefront of research into neurodegenerative disorders shared some of their latest discoveries and possible implications for treatment at the eighth annual Appel Alzheimer's Disease Research Institute Symposium, held remotely on Oct. 14.

Immune cell activity in the brain differs between males and females in ways that may explain why some neurodegenerative diseases affect the sexes differently

In the roughly 100 years since Alois Alzheimer first described the devastating neurodegenerative disease that now bears his name, scientists have developed an increasingly sophisticated understanding of the brain. 

A novel mechanism that regulates activity in the brain, discovered by Weill Cornell Medicine investigators, may help explain the origins of one common type of dementia.

As brain disorders such as Alzheimer’s disease, autism and depression increase in frequency, the synergistic fields of neurology and psychiatry may illuminate important clues that can lead to innovative treatments for these conditions.

World experts in neurodegenerative diseases gathered at Weill Cornell Medicine Sept. 25 for the sixth annual Appel Alzheimer’s Disease Research Institute Symposium, sponsored by the Appel Institute and its home department, the Feil Family Brain and Mind Research Institute. Every year, the symposium highlights the latest discoveries in the field, as researchers work their way toward a cure.

Dr. Li Gan, a neuroscientist internationally acclaimed for her research into neurodegenerative diseases, has been appointed director of the Helen and Robert Appel Alzheimer’s Disease Research Institute at Weill Cornell Medicine, effective July 1.