Research

Researchers have discovered a new cell type that may help regulate blood vessel growth in the heart during development and in response to injury, according to a study from Weill Cornell Medicine. Working with zebrafish, they found that the new cell type helps stabilize the vascular network that supplies oxygen to growing cardiac muscle.

Surgery to remove lymph nodes in the neck may interfere with cerebrospinal fluid (CSF) drainage from the brain, contributing to cognitive impairment, according to new multicenter research led by Weill Cornell Medicine scientists.

Weill Cornell Medicine investigators have determined the mechanism by which a molecule within cells can help tune the light sensitivity of the eyes.

Weill Cornell Medicine researchers have received major new funding to support collaborative efforts spanning clinical trials, precision medicine and drug target discovery with the potential to improve outcomes for patients with challenging cancers.

Chronic stress may contribute to the pain and urinary symptoms experienced by people with interstitial cystitis/bladder pain syndrome (IC/BPS) by triggering changes in the bladder and nervous system, according to a preclinical study by Weill Cornell Medicine investigators.

The biologic drug interferon-alpha can benefit patients with blood cancers called myeloproliferative neoplasms by forcing mutant blood stem cells to become shorter-lived white blood cells, according to a study by Weill Cornell Medicine investigators.

Researchers at Weill Cornell Medicine have received a $17.4 million, five-year grant from the National Institute of Allergy and Infectious Diseases to discover new approaches to shorten tuberculosis (TB) treatment, potentially making it easier for patients to complete therapy. 

Metabotropic glutamate receptors, which are important but difficult drug targets, interact in surprisingly varied ways with their principal regulatory proteins, according to two new studies led by Weill Cornell Medicine investigators.

Weill Cornell Medicine and Rutgers Health in New Brunswick have received a four-year, $3 million grant from the National Institute of Mental Health (NIMH) to build the infrastructure and resources that will accelerate discoveries about HIV-associated brain injury. 

Dr. Zachary Grinspan, associate professor of pediatrics and director of the Pediatric Epilepsy Program at Weill Cornell Medicine, has been awarded a four-year, $1.6 million CDC grant to undertake wide-reaching research aiming to produce a new, more detailed picture of childhood epilepsy.

Researchers at Weill Cornell Medicine and Hospital for Special Surgery have discovered the stem cells—unspecialized cells that can develop into specific cell types—that give rise to the body’s tendons and ligaments, the tissues connecting muscles and bones. They also found that when these stem cells become hyperactive in the lower spine, they contribute to lumbar spinal stenosis.

A commonly used systemic antifungal medication may help reduce symptoms in a subset of patients with inflammatory bowel disease (IBD) by restoring a healthier gut microbiome, according to a preliminary study by Weill Cornell Medicine investigators. 

A team of Weill Cornell Medicine investigators has developed a computer model that will help scientists more efficiently develop protein-destroying therapies, a newer type of treatment that is particularly promising for cancer.

Awards, honors and achievements for the month of August.

Obesity caused by disrupted stress-hormone rhythms is metabolically very different from obesity caused by a high-fat diet, according to a new preclinical study by Weill Cornell Medicine investigators.

Weill Cornell Medicine investigators have discovered specific mechanisms that enable the bacteria not only to survive drying but also to generate mutations linked to antibiotic resistance. 

Contrary to some predictions, the use of artificial intelligence (AI) agents could lead to more, not fewer, health care professionals working in the United States, according to a new article by a physician and health policy researcher at Weill Cornell Medicine who surveyed economic theory and the history of technology in health care.

In a Viewpoint for JAMA Psychiatry, Dr. Yunyu Xiao and colleagues make the case for Generalizable, Replicable Approaches for Suicide Behavior Prediction (GRASP): shared, publicly available infrastructure to validate, select, and sustain suicide risk models across health systems. 

Weill Cornell Medicine investigators have developed a set of molecular tools to regulate the activity of specific genes in one of the most common classes of intestinal bacteria. 

Prostate tumors can rewire amino acid metabolism to override the normal brakes on cholesterol production, a process that may fuel hormone therapy resistance, according to a study by Weill Cornell Medicine investigators.