Pathology and Laboratory Medicine

A team at Weill Cornell Medicine has mapped the location and spatial features of blood-forming cells within human bone marrow.

Certain gut-dwelling fungi flourish in severe cases of COVID-19, amplifying the excessive inflammation that drives this disease while also causing long-lasting changes in the immune system, according to a new study led by investigators at Weill Cornell Medicine and NewYork-Presbyterian.

Researchers at Weill Cornell Medicine have discovered that radiation therapy combined with two types of immunotherapy—one that boosts T cells and another that boosts dendritic cells—can control tumors in preclinical models of triple negative breast cancer, a cancer type that’s typically resistant to immunotherapy alone.

Craniosynostosis, the premature fusion of the top of the skull in infants, is caused by an abnormal excess of a previously unknown type of bone-forming stem cell, according to a preclinical study led by researchers at Weill Cornell Medicine.

The vertebral bones that form the spine are derived from a distinct type of stem cell that secretes a protein favoring tumor metastases, according to a study led by researchers at Weill Cornell Medicine.

Severe COVID-19 infection triggers changes that affect gene expression in immune system stem cells, causing long-lasting alterations in the body’s immune response, according to a new study by Weill Cornell Medicine and Jackson Laboratory investigators.

Pregnant individuals who had a previous COVID-19 infection and received a full course of COVID-19 vaccination and a booster have the strongest immune protection from the disease – and pass that protection along to their unborn babies.

Awards, honors and achievements for the month of July. 

Dr. Shawon Debnath, a research associate in pathology and laboratory medicine at Weill Cornell Medicine, has been honored with a 2023 Tri-Institutional Breakout Award for Junior Investigators

Nearly 90 percent of patients with an aggressive subtype of non-Hodgkin lymphoma had their cancer go into remission in a small phase 2 clinical trial testing a treatment aimed at making chemotherapy more effective, according to Weill Cornell Medicine and NewYork-Presbyterian investigators.

Dr. Matthew Greenblatt, an associate professor of pathology and laboratory medicine at Weill Cornell Medicine, has been awarded the Pershing Square Foundation’s Maximizing Innovation in Neuroscience Discovery (MIND) Prize to support his work studying how bone cells may influence Alzheimer’s disease progression.

Strokes cause numerous changes in gene activity in affected small blood vessels in the brain, and these changes are potentially targetable with existing or future drugs to mitigate brain injury or improve stroke recovery, according to a study led by Weill Cornell Medicine scientists.

Weill Cornell Medicine has been awarded a five-year, $4.2 million grant by the National Cancer Institute, part of the National Institutes of Health, to investigate the molecular mechanisms by which immune cells called B cells interact with Epstein-Barr virus (EBV) to cause lymphoma, particularly in people living with HIV.

Individuals who were already pregnant at the beginning of the COVID-19 pandemic had a 50 percent lower exposure to...

An experimental therapy showed promise as treatment for an aggressively spreading type of colorectal cancer in preclinical models.

The long-term immune response to SARS-CoV-2 mRNA vaccination was similar in pregnant individuals compared with non-pregnant individuals of reproductive age.

A form of blood cancer known as mantle cell lymphoma is critically dependent on a protein that coordinates gene expression, such that blocking its activity with an experimental drug dramatically slows the growth of this lymphoma in preclinical tests, according to a study from Weill Cornell Medicine researchers.

Endothelial cells—the cells that line blood vessels—grown alongside leukemia cells become corrupted and rescue the cancer cells from many chemotherapy drugs, a study by Weill Cornell Medicine investigators found.

Dr. Benjamin Kleaveland, an assistant professor of pathology and laboratory medicine at Weill Cornell Medicine, has been awarded a five-year, $2.1 million grant from the National Institute of General Medical Sciences (NIGMS) of the National Institutes of Health to investigate how cells regulate noncoding RNAs, molecules that are thought to have major roles in health and disease.

A common, spontaneous mutation in blood stem cells, which has been linked to higher risks of blood cancer and cardiovascular disease, may promote these diseases by altering the stem cells’ programming of gene activity and the mix of blood cells they produce.