Women become more susceptible to hypertension as they approach menopause, and now a preclinical study led by researchers at Weill Cornell Medicine’s Feil Family Brain and Mind Research Institute suggests that this “perimenopausal” hypertension may be driven by declines in estrogen signaling in a brain region called the hypothalamus—and may be preventable with estrogen-like treatments.
Dr. Giovanni Manfredi, the Finbar and Marianne Kenny Professor in Clinical and Research Neurology at Weill Cornell Medicine’s Feil Family Brain and Mind Research Institute, has received an Outstanding Investigator Award (R35) from the National Institutes of Health’s National Institute of Neurological Disorders and Stroke (NINDS) to study the role of mitochondrial dysfunction in brain disease.
To enable animals to shift their attention in response to changing circumstances, the prefrontal cortex of the brain helps keep track of which types of stimuli have recently been most relevant, suggests a preclinical study by Weill Cornell Medicine and NewYork-Presbyterian investigators
On its face, the logic seems straightforward. Eating too much salt can lead to high blood pressure; numerous studies have shown that having hypertension in midlife makes it more likely that you’ll develop certain forms of dementia, including Alzheimer’s disease, in later years.
A team led by scientists at Weill Cornell Medicine has made a map identifying all the different RNA molecules that are derived from each gene in the brains of mice.
Investigators on the forefront of research into neurodegenerative disorders shared some of their latest discoveries and possible implications for treatment at the eighth annual Appel Alzheimer's Disease Research Institute Symposium, held remotely on Oct. 14.
Abnormal forms of a brain-cell protein called tau, which have long been implicated in Alzheimer’s and other neurodegenerative disorders, may contribute to neurodegeneration earlier than was previously understood, by interfering with the normal dynamics of blood flow in the brain.
Neurologists traditionally have expected that patients who remain in coma after cardiac arrest have almost no chance of making a meaningful recovery if they fail to emerge from coma within a week.
The short-term risk of a second stroke following an initial minor stroke is roughly 60 percent higher for black patients compared with white patients, according to a study led by Weill Cornell Medicine and NewYork-Presbyterian researchers.
Immune cell activity in the brain differs between males and females in ways that may explain why some neurodegenerative diseases affect the sexes differently
Decreased amounts of a neurotransmitter called GABA, whose main function is to reduce activity in the brain, leads to changes in the number of neurons in the developing brain and alters signaling between them.
Weill Cornell Medicine scientists have built the first global database of clinical trials testing a rapidly expanding approach to cancer treatment that involves genetically modifying immune cells to recognize specific targets on a patient’s cancer cells and attack them.
Dr. Costantino Iadecola, director of the Feil Family Brain and Mind Research Institute and the Anne Parrish Titzell Professor of Neurology at Weill Cornell Medicine, has been recognized as a 2019 Distinguished Scientist by the American Heart Association for his outstanding contributions to cardiovascular, stroke and dementia research.
A high-salt diet may negatively affect cognitive function by causing a deficiency of the compound nitric oxide, which is vital for maintaining vascular health in the brain, according to a new study in mice from Weill Cornell Medicine researchers.
In the roughly 100 years since Alois Alzheimer first described the devastating neurodegenerative disease that now bears his name, scientists have developed an increasingly sophisticated understanding of the brain.
Dr. Hagen Tilgner is exploring how faulty building instructions for brain cells may give rise to depression, schizophrenia, Alzheimer’s disease and more
A novel mechanism that regulates activity in the brain, discovered by Weill Cornell Medicine investigators, may help explain the origins of one common type of dementia.
While heart attacks that cause classic symptoms such as pressure and pain in the chest are an established risk factor for stroke because they can lead to blood clot formation, new research by Weill Cornell Medicine and NewYork-Presbyterian investigators indicates that heart attacks that have few, if any, recognized symptoms may also increase risk.
The chemical element selenium, an essential nutrient for humans and other animals, protects the brain after a stroke and may be a basis for future stroke therapies, according to a study from scientists at Burke Neurological Institute and Weill Cornell Medicine.
