Graduate School of Medical Sciences

Weill Cornell Medicine investigators have found that two genetic variants that confer high risk of Alzheimer’s disease (AD) together trigger a harmful inflammatory response in the brain’s immune cells, particularly in females, in a preclinical model.

Stimulating a key metabolic pathway in T cells can make them work more effectively against tumors when combined with immune checkpoint inhibitor therapy, according to a preclinical study led by researchers at Weill Cornell Medicine.

A new preclinical model using CRISPR, an advanced technology that allows scientists to cut and edit genes, has given Weill Cornell Medicine researchers and their colleagues a deeper insight into how prostate cancer spreads or metastasizes.

A machine-learning tool created by Weill Cornell Medicine and Hospital for Special Surgery (HSS) investigators can help distinguish subtypes of rheumatoid arthritis (RA), which may help scientists find ways to improve care for the complex condition.

An enzyme called PGK1 has an unexpectedly critical role in the production of chemical energy in brain cells, according to a preclinical study led by researchers at Weill Cornell Medicine. 

The general anesthetic propofol may hold the keys to developing new treatment strategies for epilepsy and other neurological disorders, according to a study led by researchers at Weill Cornell Medicine and Linköping University in Sweden.

Before a cell commits fully to the process of dividing itself into two new cells, it may ensure the appropriateness of its commitment by staying for many hours—sometimes more than a day—in a reversible intermediate state, according to a discovery by researchers at Weill Cornell Medicine. 

The 2024 Business Plan Challenge accelerator program culminated in a pitch competition with five finalist teams putting their knowledge and marketing skills to the test. 

Weill Cornell Medicine scientists have uncovered the first evidence that astrocyte receptors can trigger opposite effects on cognitive function in male and female preclinical models.

On May 16, 389 expected graduates – 109 medical doctors, 46 physician assistants, 80 with doctorates and 154 with master of science degrees – in the Class of 2024 received their degrees from Weill Cornell Medicine during the institution’s annual commencement ceremony at Carnegie Hall.

A team led by researchers at Weill Cornell Medicine and the Howard Hughes Medical Institute (HHMI) Janelia Research Campus has developed and tested a high-resolution sensor for tracking the real-time dynamics of ATP levels in cells and within subcellular compartments. 

Students in the Weill Cornell Graduate School of Medical Sciences' Class of 2024 were honored for their academic achievements during its convocation ceremony on May 15.

A team co-led by researchers at Weill Cornell Medicine and the New York Genome Center has developed an advanced method for revealing how gene mutations disrupt the normal packaging of DNA. 

Researchers at Weill Cornell Medicine have discovered in a preclinical model that cytokines, proteins that control immune response, circulating in maternal blood during pregnancy may mitigate an offspring's risk for psychiatric conditions.

Microbes in the mammalian gut can significantly change their hosts’ amino acid and glucose metabolism, acting almost like an extra liver, according to a new preclinical study by Weill Cornell Medicine investigators.

Dr. Carl Nathan, chair of the department of microbiology and immunology and the R.A. Rees Pritchett Professor of Microbiology at Weill Cornell Medicine, answers questions about interferon-γ's history and future.

Weill Cornell Medicine’s Celebration of Diversity, part of the institution’s sixth annual Diversity Week, was held on April 15. The awardees were honored for their commitment to diversity and inclusivity in academic medicine through exemplary contributions in mentorship, research, clinical care, community service and advocacy.

Weill Cornell Medicine investigators have uncovered a way to unleash in blood vessels the protective effects of a type of fat-related molecule known as a sphingolipid, suggesting a promising new strategy for the treatment of coronary artery disease.

Launched in 2019, the IMSD Program aims to boost admissions and retention rates of doctoral students primarily from self-identified historically underrepresented groups in science. 

Weill Cornell Medicine scientists have developed an innovative human neuron model that robustly simulates the spread of tau protein aggregates in the brain—a process that drives cognitive decline in Alzheimer's disease and frontotemporal dementia.