News from WCM

The grant will enable researchers to study a new approach for delivering an experimental non-opioid pain medication, called BP4L-18:1:1, to relieve neuropathic pain. 

The initiative provides physician-scientists with extended periods of dedicated time to pursue research that is financially compartmentalized from their clinical responsibilities.

Weill Cornell Medicine researchers have designed an AI system that could help clinical laboratories identify...

Researchers have found a surprisingly common vulnerability in a broad variety of cancers and have begun designing drug compounds to exploit it, in a study led by investigators at Weill Cornell Medicine. 

A family of mutations seen in about 20% of human cancers drives malignancy by changing the accessibility of genes to a particular regulatory protein, according to a study by Weill Cornell Medicine investigators.

As Stan Au’s Parkinson’s disease symptoms progressed, everyday activities became daily battles. His hands shook so badly that he struggled to hold utensils and couldn’t sign his name. He stopped playing pickleball—a sport he once enjoyed—despite taking a widely prescribed medication for managing motor symptoms.

Weill Cornell Medicine has received a four-year, $8.2 million grant from the National Institute of Child Health and Human Development (NICHD) to develop and test an experimental on-demand male contraceptive pill that temporarily stops sperm in their tracks.

Researchers at Weill Cornell Medicine have identified a molecular pathway that contributes to the death of insulin-producing beta cells in the pancreas. Experiments with preclinical models and human pancreatic cells found that blocking certain proteins in the pathway helped protect beta cells from excessive cellular stress. 

Losartan, a drug commonly prescribed for high blood pressure, boosts brown adipose tissue or “brown fat” activity and enhances its metabolism, according to a preclinical study by Weill Cornell Medicine, Rockefeller University and Memorial Sloan Kettering Cancer Center researchers. 

Parents of children with mental health problems may experience stigma when the ideals that matter most to being considered a “good parent” are perceived as not being met, according to preliminary research led by Weill Cornell Medicine, Columbia University Vagelos College of Physicians and Surgeons and NewYork-Presbyterian investigators.

Dr. Robbie Majzner, an esteemed physician-scientist whose research focuses on children with intractable cancers, has been awarded the 11th annual Gale and Ira Drukier Prize in Children’s Health Research by Weill Cornell Medicine.

An experimental opioid painkiller designed to be reversibly switched on and off with different light frequencies, keeping its action local and out of the brain, may eliminate the dangerous side effects that characterize current opioids, according to a study led by Weill Cornell Medicine and University of Pennsylvania investigators.

A scientist at Weill Cornell Medicine is working with colleagues at the University of Massachusetts Amherst on new, complementary research efforts engineering therapeutic Salmonella to target critical gaps in treatment for drug-resistant triple-negative breast cancers. 

Dr. Samie Jaffrey, the Greenberg-Starr Professor in the Department of Pharmacology at Weill Cornell Medicine, has received a five-year, $5.5 million NIH Director’s Transformative Research Award for the comprehensive study of how messenger RNAs are regulated in cells by small molecules called metabolites.

Dr. Olivier Elemento, the director of the Englander Institute for Precision Medicine at Weill Cornell Medicine, has been awarded an NIH Director's Pioneer Award to build an artificial intelligence (AI) tool to accelerate cancer research, starting with lung cancer.

Researchers have discovered a new cell type that may help regulate blood vessel growth in the heart during development and in response to injury, according to a study from Weill Cornell Medicine. Working with zebrafish, they found that the new cell type helps stabilize the vascular network that supplies oxygen to growing cardiac muscle.

Surgery to remove lymph nodes in the neck may interfere with cerebrospinal fluid (CSF) drainage from the brain, contributing to cognitive impairment, according to new multicenter research led by Weill Cornell Medicine scientists.

Weill Cornell Medicine investigators have determined the mechanism by which a molecule within cells can help tune the light sensitivity of the eyes.

Weill Cornell Medicine researchers have received major new funding to support collaborative efforts spanning clinical trials, precision medicine and drug target discovery with the potential to improve outcomes for patients with challenging cancers.

Chronic stress may contribute to the pain and urinary symptoms experienced by people with interstitial cystitis/bladder pain syndrome (IC/BPS) by triggering changes in the bladder and nervous system, according to a preclinical study by Weill Cornell Medicine investigators.