News from WCM

A small subset of T cells, called stem T cells, are responsible for making new T cells and for continuously replenishing them in chronic disease, according to a team of scientists from Weill Cornell Medicine and Memorial Sloan Kettering Cancer Center.

Researchers at Columbia University Irving Medical Center and Weill Cornell Medicine have won a $17.25 million grant from the Aligning Research to Understand Autism initiative to study profound autism, which affects over one quarter of individuals who are on the autism spectrum. 

Patients with advanced prostate cancer may need periodic imaging scans to catch tumor growth even with stable levels of prostate-specific antigen (PSA), a protein in the blood that doctors routinely monitor for cancer progression, according to an analysis led by researchers at Weill Cornell Medicine and Duke University.

Chronic psychological stress can help tumors evade immune attack through a chain of molecular events involving gut bacteria and viruses within those bacteria, according to a study led by Weill Cornell Medicine investigators.

Over the last two decades, the Weill Cornell Community Clinic has become a bedrock of care for uninsured New Yorkers while also evolving into a deeply embedded part of medical education at Weill Cornell Medical College. 

Loss of GATA6—a transcription factor that controls which genes are turned on or off—can reprogram colorectal cancer cells into more primitive, adaptable states that can then spread to the liver and establish new tumors, according to Weill Cornell Medicine and Massachusetts Institute of Technology (MIT) researchers.

A recent paper examines the academic, economic and organizational forces jeopardizing a career as a physician-scientist and proposes a framework with the potential to both remedy and revitalize this unique workforce.

A new single-protein analysis technique gives researchers an unprecedented ability to study proteins called scramblases, which have critical roles in biology. The development of the new technique, in a study led by investigators at Weill Cornell Medicine and Ruhr University Bochum in Germany, expands the toolkit available to cell biologists and biophysicists and could someday be useful in devising new strategies against multiple diseases.

Prostate-targeted, engineered nanoparticles made of amorphous silica are effective in killing prostate tumors directly while enhancing anti-tumor immunity, according to a preclinical study led by investigators at Weill Cornell Medicine and the Cornell Duffield College of Engineering. 

The eighth cohort of the Biomedical Innovation Challenge showcased its innovations and development plans during a lightning round of pitches and judges’ questions on June 4 in the Belfer Research Building.

A new gene therapy appears to be safe in patients diagnosed with Friedreich ataxia cardiomyopathy, a progressive and fatal inherited cardiac disease, according to a phase 1 clinical trial led by Weill Cornell Medicine researchers. 

A carefully designed metal-free carbon monoxide prodrug—an inactive compound that is converted into its active form in the body—may help prevent some of the deadliest forms of cancer from spreading, according to researchers at Weill Cornell Medicine.

A circuit that runs from the prefrontal cortex near the front of the brain to a deeper brain structure called the insular cortex appears to mediate the antidepressant effects of a newer form of transcranial magnetic stimulation (TMS), according to a study led by Weill Cornell Medicine investigators.

The majority of national climate adaptation plans fail to fully integrate health needs or engage populations most at risk from climate change, found an international team of investigators led by Weill Cornell Medicine.

Extreme heat and cold are growing cardiovascular risks that can trigger heart attacks, strokes, heart failure and sudden cardiac death, according to a recent scientific statement by experts at Weill Cornell Medicine and other leading institutions. 

A new technology allows scientists to map, in single cells, the DNA binding sites of transcription factors and other regulatory proteins that control gene activity, according to a study led by investigators at Weill Cornell Medicine and the New York Genome Center.

The ASCERTAIN V clinical trial, led by Weill Cornell Medicine researchers, demonstrated that an all-oral drug combination for older patients with acute myeloid leukemia (AML) is an effective alternative to the current standard, which requires repeated hospital or office visits for intravenous treatment. 

Obtaining home care for older adults with Medicaid can be a complex, multi-step process marked by delays and uncertainty, often resulting in long wait times, according to a new Weill Cornell Medicine study.

Weill Cornell Medicine received a five-year, $5 million grant from the National Cancer Institute, part of the National Institutes of Health, to develop innovative support strategies for an understudied group of cancer patients: adolescents and young adults (AYAs).

Scientists and physicians should advocate to protect the vaccine research infrastructure that has saved an estimated 154 million lives over the past 50 years, according to a new commentary by researchers at Weill Cornell Medicine and the University of Washington.