Dr. Lisa Mosconi

Estrogen-based menopause hormone therapy for women in mid-life should be investigated more thoroughly as a potential strategy for preventing Alzheimer’s disease, the most common form of dementia, according to a new analysis from researchers at Weill Cornell Medicine.

The drop in estrogen levels that occurs with menopause brings declines in the volumes of “gray matter,” the cellular matter of the brain, in key brain regions that are also affected in Alzheimer’s disease. But a new study from Weill Cornell Medicine researchers, in collaboration with the University of Arizona, suggests that greater cumulative exposure to estrogen in life

The transition from pre- to post-menopause, with its steep decline in estrogen production, involves myriad changes to brain structure, brain-region connectivity, and brain energy consumption, though many of these changes are only temporary, a study led by researchers at Weill Cornell Medicine has found.

The hormonal shifts that occur with menopause can increase the risk of brain changes associated with Alzheimer’s disease, according to new research from Weill Cornell Medicine investigators.

Neuroscientist Dr. Lisa Mosconi explores why women have a much higher risk of Alzheimer’s disease than men.

A Western-style diet triggers changes in the brain that may predispose patients to Alzheimer’s disease decades before they show any sign of cognitive decline, according to new research by Weill Cornell Medicine investigators.