Dr. Minkyung Song

In this illustrated model, T cells afflicted by harsh conditions inside the tumor experience endoplasmic reticulum (ER) stress, symbolized here by the “burning” ER (orange) surrounding the nucleus (purple and turquoise). Severe ER stress responses driven by IRE1a-XBP1 pathway signaling alter the function of mitochondria (blue-gray) and consequently limit optimal T cell responses to cancer cells (red).

Ovarian Cancer Thwarts Immune Cells by Revving up Stress

October 10, 2018

Ovarian tumors disable the immune system’s killer T cells—which protect the body by destroying infected or malignant cells—enabling the disease to flourish unchecked, according to a new study by Weill Cornell Medicine scientists.

Dr. Juan R. Cubillos-Ruiz
Dr. Minkyung Song
Research
Sandra and Edward Meyer Cancer Center
News from WCM

Dr. Juan R. Cubillos-Ruiz, Dr. Minkyung Song, Research, Sandra and Edward Meyer Cancer Center, News from WCM

Weill Cornell Medicine
Office of External Affairs 1300 York Avenue
Box 314 New York, NY 10065 Phone: (646) 962-9476