Weill Cornell Doctors Identify a Likely Genetic Cause of Atherosclerosis

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Led by Dr. Timothy McCaffrey, associate research professor of cell biology in the Department of Medicine, Weill Cornell researchers have discovered a probable molecular cause of atherosclerosis in elevated levels of a gene found in coronary and carotid lesions that appear to disrupt normal vascular repair. Recently published in The Journal of Biological Chemistry, the research may result in new drug therapies or genetic interventions for preventing or reversing heart disease. It also may explain the molecular mechanism behind some forms of cancer. Atherosclerosis contributes to more than 950,000 deaths per year in the United States.

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