Biochemistry

A new study identified a set of 140 genes that may help predict enhanced disease-free survival in patients with non-small cell lung cancer (NSCLC) treated with a combination of immunotherapy and low-dose radiation.

A new study reported that patients with non-small cell lung cancer (NSCLC) treated with a combination of low-dose radiation and immunotherapy had higher progression-free survival compared to patients who received immunotherapy alone two years after treatment. 

A preclinical study by Weill Cornell Medicine investigators shows that a specific human genetic variant of a receptor that stimulates insulin release may help individuals be more resistant to obesity. The researchers discovered that this variant behaves differently in the cell which may contribute to more efficient metabolism.

Dr. David Simon, the Fernholz Foundation Research Scholar in Neuroscience and an assistant professor of biochemistry at Weill Cornell Medicine, was awarded the 2023 Pershing Square Sohn Prize for Young Investigators in Cancer Research on May 16.

Dr. Tobias Meyer, the Joseph C. Hinsey Professor in Cell and Developmental Biology at Weill Cornell Medicine, has been elected to the American Academy of Arts and Sciences.

Obesity may spur DNA damage in the breast tissue of women who carry BRCA1 or BRCA2 mutations, possibly contributing to breast cancer development in this already high-risk group.

A protein that prepares DNA for replication also prevents the replication process from running out of control, according to a new study by Weill Cornell Medicine researchers.

A multidisciplinary team of Weill Cornell Medicine researchers has received a five-year $5.7 million grant from the National Cancer Institute at the National Institutes of Health to fund a center aimed at developing messenger RNA (mRNA) vaccines to deter cancer development in at-risk groups.

A mitochondrial gene plays a crucial role in genetic susceptibility to Zika, Dengue, and SARS-CoV-2 infections, a study by Weill Cornell Medicine investigators showed.

Disruption of the circadian clocks that keep the body and its cells entrained to the 24-hour day-night cycle plays a critical role in weight gain, according to a pair of studies by Weill Cornell Medicine investigators.  

SARS-CoV-2 infections of women in late pregnancy frequently spread to their placentas and led to inflammation.

The SARS-CoV-2 virus can infect specialized pacemaker cells that maintain the heart’s rhythmic beat, setting off a self-destruction process within the cells, according to a preclinical study co-led by researchers at Weill Cornell Medicine, NewYork-Presbyterian and NYU Grossman School of Medicine.

Tumors can use an enzyme called ART1 to thwart antitumor immune cells, making the enzyme a promising new target...

Pound for pound, the brain consumes vastly more energy than other organs, and, puzzlingly, it remains a fuel-guzzler even when its neurons are not firing signals called neurotransmitters to each other. Now researchers at Weill Cornell Medicine have found that the process of packaging neurotransmitters may be responsible for this energy drain.

Researchers at Weill Cornell Medicine have shown that they can record the high-speed motions of proteins while correlating their motion to function.

Endocrinology Chief Dr. Laura Alonso—A specialist in diabetes research and treatment—is exploring ways to restore the body’s insulin production

The study of human pluripotent stem cells, which can develop into any cell type in the body, is providing Weill Cornell Medicine and NewYork-Presbyterian investigators with new insights into the virus that causes COVID-19 and how it may infect organs such as the pancreas and liver.

A new technology developed by Weill Cornell Medicine and Max Planck Institute for Medical Research scientists allows the controlled, on-and-off “switching” of neural receptors with unprecedented efficiency and precision. 

A prestigious Cancer Moonshot grant from the National Cancer Institute’s Immuno-Oncology Translational Network will enable investigators to explore the mechanisms that allow slow-growing lung cancer lesions to progress into aggressive malignancies and identify new therapeutic strategies to intercept the transition. 

An enzyme found in brain cells can break apart the precursors to plaques that accumulate in the organ and cause toxicity in Alzheimer’s disease, according to a new study led by Weill Cornell Medicine scientists.